Kiki Fatmala started her career in the film industry at the age of 21, precisely in 1988. The first film she starred in was Permainan di Balik Tirai (The Game Behind the Curtain). In the same year, the artist of Sundanese-Minahasa and Pakistani-Iranian descent starred in 5 film titles.

Apart from acting in movies, Kiki Fatmala also starred in 16 soap operas. The first soap opera she played in was "Ada-ada saja" which aired from 1922 to 1994. The last soap opera she played in was "Oh Ternyata" in 2012.

Kiki Fatmala starred in the soap opera Si Manis Jembatan Ancol from 1994 to 1999. In this soap opera, she played the role of Mariam. Her name became more well-known to the public since she started acting in this soap opera.

Kiki Fatmala is a specialist in horror and comedy films. Because she has starred in more than 50 film titles and soap operas.

No longer exist in the entertainment world, Kiki Fatmala used to be a fitness instructor because of her love for sports. She even had a fitness studio.