Mengenal Terapi Pengobatan Baru untuk Pasien Penyakit Ginjal Kronis (PGK)

"Getting to Know New Treatment Therapy for Chronic Kidney Disease (CKD) Patients (PGK)"

"Dream - Indonesia ranks 5th with the highest number of diabetes cases in the world, around 19.5 million people in 2021 and estimated to reach 28.6 million people in 2045."

The following is the translation of the text from 'Bahasa' to 'English' while preserving the HTML tags: "The case of diabetes is often only realized by patients when their condition has become severe. It could already be in the main microvascular complication stage, or in Type 2 Diabetes patients with Chronic Kidney Disease (CKD)."

PGK itself is a condition of gradual loss of kidney function. If experiencing PGK, patients begin to lose kidney function to filter waste and excess fluid from the blood, which is then excreted through urine. The disease that occurs in the kidneys initially has no symptoms, as a result, many people are unaware that they have kidney disorders.

Until now, many people still do not realize how important it is to maintain kidney health and what needs to be done if their kidney function declines.

Moreover, for those who have hypertension and diabetes. PGK is also recorded as the cause of 4.6% of deaths in global cases, which is one of the highest causes of death in the world. It is no wonder that this disease is often referred to as a silent killer.

"And this will still continue to develop due to pre-diabetes. Therefore, be careful in consuming food," said Dr. Ketut Suastika, Internal Medicine Specialist, Metabolic and Endocrinology Consultant, in the talk show event on Innovative Treatment for Slowing the Progression of Chronic Kidney Disease (CKD) with Type 2 Diabetes, in Jakarta, January 15, 2024."

"For prevention, since young age, make sure to consume a balanced daily intake, especially sugar and salt consumption, do not overdo it. Keep track of the calorie intake of food according to your needs."

Therapy for PGK Patients

"For those who have been diagnosed with chronic kidney disease (CKD), they definitely need intensive treatment. This is to prevent further deterioration of kidney function and maintain quality of life. Do not let kidney function continue to decline or experience progression."

"The main cause of progression in CKD in type 2 diabetes patients is the occurrence of inflammation and fibrosis in the kidneys. When fibrosis occurs, it means there is a failure in the response of the healing and repair functions that exist in the kidneys. As a result, the progression towards kidney failure will be faster. Three combined effects that can worsen CKD are metabolic, hemodynamic, as well as inflammation and fibrosis," said Dr. Pringgodigdo Nugroho, Internal Medicine Specialist and Kidney and Hypertension Consultant, on the same occasion.

One of the treatments that can be done is drug therapy that has just been released by Bayer. It is a treatment with Finerenone, claimed to help reduce the risk of inflammation and fibrosis.

"Finerenone from Bayer is the first nonsteroidal Mineralocorticoid Receptor Antagonist (MRA) approved by BPOM for CKD associated with type 2 diabetes in adults," said Dr. Dewi Muliatin Santoso, Head of Medical Dept. Pharmaceutical Division PT Bayer Indonesia.

This medicine, according to Dr. Dewi, can block a group of proteins called mineralocorticoid receptors. Increased stimulation of mineralocorticoid receptors is known to trigger injury and inflammation in the kidneys, thus playing a role in the progression of PGK. Finerenone itself is a form of oral medication and has been authorized for circulation. "Finerenone is now available in several hospitals in Indonesia, it is widely distributed. And especially, we have it in private hospitals," said Dr. Dewi. Report: Monica Alycia Mutiara.

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